Cláudio Miguel da Costa Neto, Professor, FMRP-USP
Lines of Research:
- Molecular biology of the renin-angiotensin system and G-protein coupled receptors;
- Signal transduction;
- Molecular biology of cancer-linked proteins and analysis of new compounds with anti-tumor action.
Our laboratory (7tmr-Lab; www.claudiocostaneto-lab.com) studies different aspects of cellular signaling, mainly g-protein coupled receptors (GPCRs). As a reference to the importance of GPCRs, currently about 40% of all drugs available on the market target this family of receptors and 50% of all global research for the discovery of new drugs targets GPCRs.
Our laboratory develops different strategies, such as site-directed mutagenesis (genetic engineering) on receptors, in addition to the design and synthesis of new ligands/drugs for these receptors, state-of-the-art analysis of different signaling pathways. For these studies, we have important collaborations in Brazil, France, Switzerland, and Canada.
Our goal is to map and discover new signaling pathways and identify those that, when activated or blocked, may influence some diseases; when we then develop experiments for study in cardiovascular, inflammatory, and cancer diseases.